Sperm donor genetic mutation was related to cancer in 10 conceived children

The sperm of a single donor has been used to conceive at least 67 pregnancies, although the donor had a rare mutation that caused cancer.

The donor’s mutation has been related to cancer diagnoses in ten of these children, according to a report by The Guardian.

The case was released after two families contacted their fertility clinics after their children’s cancer diagnoses were related to a rare genetic variant called TP53.

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A mutation in the TP53 gene causes Li-Fraumeni syndrome, which increases the risk of developing cancer. The Cleveland Clinic claims that this disorder is 90% likely to develop some type of cancer at the age of 60 and 50% chance at the age of 40.

The European Sperm Bank, the Sperm Supplier, confirmed that this variant was present in some of the donor’s sperm.

The Guardian reported that the rare variant “was not known to be linked to cancer at the time of donation in 2008”.

The genetic variant would not have been detectable by standard screening and the donor is said to be in good health.

“The identified mutation is one that could not have been detected by the screening methods we use in accordance with the regulations.”

Dr. Edwige Kasper, a biologist at Rouen University Hospital in France, presented this case at the annual conference of the human genetics society of human society in Milan last week, commenting on the need for a European limit on the number of births or families for a single donor.

“We cannot make whole genomes sequencing for all sperm donors; I don’t discuss that,” he told The Guardian. “But this is the abnormal diffusion of genetic disease. Not all men have 75 children throughout Europe.”

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Kasper analyzed the mutation of his laboratory, concluding that cancer probably produced and that children born of this donor should “receive genetic advice”.

The investment converted into research monitored 67 children from 46 families from eight European countries. The children were tested, with the variant detected in 23 of them.

The ten that had been diagnosed with cancer included cases of leukemia and non -Hodgkin lymphoma.

In a statement sent to Fox News Digital, the European Sperm Bank stated that donors assisted reproduction “is generally a significantly more secure alternative” than reproduction without genetic screening.

The bank added that sperm donors undergo a “comprehensive health screening”, which includes an in -depth medical examination, a review of the donor’s family medical history, and the “extensive” tests of genetic and infectious diseases.

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“However, it is not possible to rule out all risks, and in this particular case, the identified mutation is one that could not have been detected by the screening methods we use in accordance with the regulations and would require specialized genetic evidence,” said the group.

JULIE PAULLI BUDTZ, VP. of the corporate communications of the European Sperm Bank, expressed in Fox News Digital News that are “deeply affected by this case”.

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“The donor has thoroughly tested even beyond the necessary standards, but preventive genetic screening reaches its limits here,” he said.

“Each human being has about 20,000 genes and simply it is not possible to detect mutations that cause disease in the pool of genes of a person if you do not know what you are looking for.”

Budtz said that the European Sperm Bank is home to “continuous dialogue” on the definition of an “internationally binding family limit”, which they have defended on several occasions, also at the EU level. ”

“This is also why, in addition to fulfilling the national pregnancy limits, we have proactively implemented our own international limit of 75 families to donating,” he added.

What to know about sperm donation guidelines in the United States

In the US, there is no official legal limit of how many sperm donations can make a man.

However, the American Society for Reproductive Medicine (ASRM) recommends that donors be limited to 25 living births within each population area of ​​800,000 people.

“Institutions, clinics and sperm banks should keep sufficient records to allow a limit to be established for the number of pregnancies for which a given donor is responsible,” says ASRM on its website.

“Limiting donors’ roads is an important part of the process.”

California Cryobank, who has stated to have the largest selection of sperm donations and eggs in the country, states on its website that it monitors donors closely to limit the total number of family units to 20 to 30 worldwide.

“Limiting donors’ roads is an important part of the process,” said the bank.

The Federal Drug Administration (FDA) in the United States requires all sperm donors to undergo a physical examination, complete a questionnaire, provide their medical history and submit projections for infectious diseases in an FDA approved laboratory.

In addition, ASRM suggests that donors are undergoing psychological and genetic screening, and also recommends doing infectious evidence of the recipient’s disease and the sexually intimate partners of the recipient, on its website.

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“Legal consultation and laws may vary depending on the state,” says the organization.

In California Cryobank, donors must be proved for infectious diseases, undergoing genetic screening, obtaining a psychological evaluation, and checking criminal antecedents and receiving screening from the Zika virus, according to the bank’s website.